An Aminopeptidase, ARTS-1, Is Required for Interleukin-6 Receptor Shedding

An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding.

Aminopeptidase regulator of TNFR1 shedding (ARTS-1) binds to the type I tumor necrosis factor receptor (TNFR1) and promotes receptor shedding. Because hydroxamic acid-based metalloprotease inhibitors prevent shedding of both TNFR1 and the interleukin-6 receptor (IL-6Ralpha), we hypothesized that ARTS-1 might also regulate shedding of IL-6Ralpha, a member of the type I cytokine receptor superfam...

Type 1 Shedding Aminopeptidase Regulator of TNF Receptor Requires a Multifunctional Aminopeptidase, Shedding of the Type II IL-1 Decoy Receptor

Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding.

Proteolytic cleavage of the extracellular domain of the type II IL-1 decoy receptor (IL-1RII) generates soluble IL-1-binding proteins that prevent excessive bioactivity by binding free IL-1. In this study we report that an aminopeptidase, aminopeptidase regulator of TNFR1 shedding (ARTS-1), is required for IL-1RII shedding. Coimmunoprecipitation experiments demonstrate an association between en...

Interleukin-6 receptor shedding: a possible role for members of the ADAM family.

Introduction Interleukin-6 (IL-6) is a cytokine that was originally identified as a factor that could induce B lymphocytes to differentiate into immunoglobulin-producing plasma cells [ 11. Subsequent studies have shown IL-6 to be a multifunctional cytokine that is produced by, and can affect, a range of different cells [2,3]. IL-6 is the original member of a family of cytokines that now include...

Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice.

Interleukin (IL)-1, a proinflammatory cytokine, is expressed in the lung after ozone (O(3)) exposure. IL-1 mediates its effects through the type I IL-1 receptor (IL-1RI), the only signaling receptor for both IL-1alpha and IL-1beta. The purpose of this study was to determine the role of IL-1RI in pulmonary responses to O(3.) To that end, wild-type, C57BL/6 (IL-1RI(+/+)) mice and IL-1RI-deficient...